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The biggest difference between Prilosec and Nexium was price when reviewed.
I have been having the same problems with switching to over the counter Nexium from a script because insurance won't pay for it anymore, even with a Doctor's preauthorization the copay is way too much for most people to swallow.
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Under the terms of the agreement, Pfizer will acquire the exclusive global rights to market NEXIUM for the approved over-the-counter indications in the United States, Europe and the rest of the world.
Although over-the-counter Nexium does not exist, Prilosec OTC, Prevacid 24HR, or Zegerid OTC can be used as over-the-counter alternatives for relieving heartburn.